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CERENEO PREVENTION

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Innovation is more than just a buzzword for us. Equipped with our own clinical research team and thanks to our close research collaborations, we not only implement innovative technologies into our practice as quickly as possible, but also test their effectiveness in treatment.

Research objectives

The goal of our research partnerships is to develop a novel form of Neurorehabilitation that seamlessly integrates into our patients' daily lives. They train independently by being as active as possible. Intelligent technology and interaction with their therapists ensure the necessary corrective feedback, support, and safety measures.

We continuously participate in innovative research collaborations and projects in cooperation with renowned educational institutions worldwide and always strive for the highest quality in Neurorehabilitation , based on the latest scientific developments.

Motivation

Patients need to be self-motivated to be active in their daily lives. Our motivation research focuses on innovative therapeutic approaches that encourage and promote active training and physical activity in everyday life.

Take responsibility

We continuously participate in innovative research collaborations and projects in cooperation with renowned educational institutions worldwide and always strive for the highest quality in Neurorehabilitation , based on the latest scientific findings.

Research collaborations

Close collaboration with various departments, such as D-HEST or RESC. Projects include, among other things, the development of sensor technologies for monitoring Stroke patients in everyday life.
Together with Johns Hopkins University, cereneo is conducting randomized clinical trials in the field of arm rehabilitation using new robotic training approaches.
Collaboration with Geert Verheyden, who leads a research focus on sensorimotor deficits and their assessment, restoration and Rehabilitation in the upper extremity after a Stroke .
The Lake Lucerne Institute (LLUI) is a private research and training center for Neurorehabilitation . It works closely with the cereneo Clinic and serves as a platform to translate research and teaching into practice.
Together with the LOOP Zurich Medical Research Center, cereneo is conducting a study to significantly improve precision rehabilitation through personalized stimulation loops.
For acute orthopedic questions and examinations, we cooperate with the Schulthess Clinic , the leading Clinic for orthopedics.
We cooperate with the University Hospital Zurich (USZ) in a variety of ways and on numerous projects. This includes, in particular, the treatment of stroke patients with the Zurich Stroke center and the provision of high-quality, gold-standard Parkinson's therapies at the USZ in combination with long-term rehabilitation programs at the Cereneo Clinic .
In collaboration with CERENEO PREVENTION, we focus on evidence-based prevention concepts for long-term brain health. Our emphasis is on targeted neuroprevention with the goal of maintaining cognitive performance, mental clarity, and Quality Of Life well into old age. Through this close cooperation, we combine medical expertise with innovative prevention strategies – for a strong brain at every stage of life.

The latest technology in stroke rehabilitation

Our neurorehabilitation clinic are equipped with state-of-the-art motion analysis technology, robotic systems and other innovative equipment to complement practical training with the therapist.

CAREN

The innovative CAREN offers powerful gait and Balance Training with progress virtual and augmented reality, a 6-DOF motion base and a high-performance treadmill.

ZeroG® by Aretech

This innovative gait training device for outdoor use helps train mobility and balance. Dynamic partial body weight support (DBWS) reduces the risk of falls and simultaneously provides patients with a realistic experience.

Treadmill with split treadmill

Training on a split-belt treadmill with different speeds for each leg can trigger adaptations in the brain that lead to a more symmetrical gait pattern. After a stroke this can be used to speed up walking and reduce effort.

Current stroke research projects

Together with the cereneo Institute for Interdisciplinary Research (cefir), the University Hospital Zurich and ETH Zurich, we conduct basic and clinical research, including randomized controlled trials to test new training and Diagnosis methods.

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Precision training

The training relies heavily on feedback from the therapists, which in turn is based on observation and experience.

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Diagnosis sensors

The continuous assessment of neurological impairments and disabilities forms the basis of targeted and successful rehabilitation therapy.

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Reward-based training

Based on the findings from our basic research program, we suspect that training can be improved through rewards and the associated increase in training motivation.

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Recent publications

A translational roadmap for the use of precise, non-invasive brain stimulation (NIBS) in Stroke rehabilitation

Dr. Meret Branscheidt, Medical Director at the cereneo Rehabilitation Center Hertenstein, was part of the NIBS roundtable expert team that developed a translational roadmap for the use of precise, non-invasive brain stimulation (NIBS) in Stroke rehabilitation . The outcome of this expert roundtable is five key recommendations for the use of NIBS, aiming to adapt NIBS to the specific needs of patients using the same measurement set, in order to better track outcomes and compare different studies.
At cereneo, Dr. Meret Branscheidt successfully uses the various NIBS techniques in the cereneo Rehabilitation clinic in Switzerland to support the Recovery of Stroke patients.

Automated and quantitative assessment of tactile mislocalization after a Stroke

This is a case report by Mike D. Rinderknecht, Julio A. Dueñas, Jeremia P. Held, Olivier Lambercy, Fabio M. Conti, Leopold Zizlsperger, Andreas R. Luft, Marie-Claude Hepp-Reymond, and Roger Gassert. The report describes a novel automated assessment tool for tactile mislocalization in neurological patients with somatosensory deficits following a Stroke . The automated assessment tool enables the identification, localization, precise quantification, and visualization of patients' topesthesia deficits, which can be severely affected by neurological damage such as Stroke .

Rethinking interhemispheric imbalance as a goal of Stroke Neurorehabilitation

This longitudinal study by Jing Xu, Meret Branscheidt, Heidi Schambra, Levke Steiner, Mario Widmer, Jörn Diederichsen, Jeff Goldsmith, Martin Lindquist, Tomoko Kitago, Andreas R. Luft, John W. Krakauer, and Pablo A. Celnik aims to investigate interhemispheric interactions in Stroke patients by tracking their pre-movement interhemispheric inhibition (IHI) for one year post- Stroke . An inhibitory imbalance observed in patients with chronic Stroke appears to correlate with poor motor performance and represents a target for therapeutic interventions.

Differential motor recovery after a Stroke in an arm versus a hand muscle in the absence of motor evoked potentials

This study by Heidi M. Schambra, Jing Xu, Meret Branscheidt, Martin Lindquist, Jasim Uddin, Levke Steiner, Benjamin Hertler, Nathan Kim, Jessica Berard, Michelle D. Harran, Juan C. Cortes, Tomoko Kitago, Andreas Luft, John W. Krakauer, and Pablo A. Celnik aims to determine whether the presence or absence of motor evoked potentials (MEPs) differentially affects the recovery of voluntary contraction and strength in an arm muscle compared to an intrinsic hand muscle. The recovery of movement in proximal and distal muscles of the upper extremity after a Stroke appears to follow different time trajectories, suggesting differences in their neuronal substrates.

Characterization of Stroke -related motor impairments of the upper extremities during various upper extremity activities using kinematic core set measurements

This prospective cross-sectional observational study by Anne Schwarz, Miguel MC Bhagubai, Saskia HG Nies, Jeremia PO Held, Peter H. Veltink, Jaap H. Buurke, and Andreas R. Luft aims to comprehensively characterize the spatiotemporal kinematics of Stroke patients during everyday upper extremity activities. To this end, kinematic characteristics were investigated with regard to different movement types and degrees of impairment, both for the entire task and for individual movement phases.

Development and prediction of the discrepancy between observed and perceived upper arm function after a Stroke : a prospective, longitudinal observational study

A prospective, longitudinal observational cohort study by Bea Essers, Annick Van Gils, Christophe Lafosse, Marc Michielsen, Hilde Beyens, Fabienne Schillebeeckx, Janne M. Veerbeek, Andreas R. Luft, Daphne Kos, and Geert Verheyden aimed to investigate the development of a group of Stroke patients over six to twelve months and to identify factors influencing their Admission to inpatient Rehabilitation . An identified "mismatch" group of patients with good observed upper extremity motor function but low perceived upper extremity activity six months post- Stroke tends to use the affected upper extremity less in daily life than would be expected based on clinical tests. The study seeks to confirm the importance of addressing the individual needs of these patients.

Rehabilitation of Walking Impairment using Augmented Reality: Case Report

This study by Jeremia Philipp Oskar Held, Kevin Yu, Connor Pyles, Janne Marieke Verbeek, Felix Bork, Sandro-Michael Heining, Nassir Navab, and Andreas R. Luft aims to (1) investigate the influence of virtual augmentation on the gait pattern of post- Stroke individuals while walking on level ground compared to walking without augmented reality (AR) performance feedback, and (2) assess the usability of the AR system. Improving balance and gait is one of the most important goals of post- Stroke Rehabilitation .

Technology-assisted assessment of functionally relevant sensorimotor impairments in the arm and hand in patients after a Stroke

This study by Christoph M. Kanzler, Anne Schwarz, Jeremia PO Held, Andreas R. Luft, Roger Gassert, and Olivier Lambercy investigates the ability of the Virtual Peg Insertion Test (VPIT) to characterize sensorimotor impairments of the arm and hand relevant to the performance of functional tasks after a Stroke . Assessing functionally relevant sensorimotor impairments of the arm and hand is essential for optimizing the effectiveness of neurorehabilitative interventions. The VPIT addresses existing limitations and quantifies movements during a goal-directed manipulation task.

Consensus-based core set of outcome measurements for clinical motor Rehabilitation after Stroke – A Delphi study

This Delphi study by Johannes Pohl, Jeremia Philipp Oskar Held, Geert Verheyden, Margit Alt Murphy, Stefan Engelter, Agnes Flöel, Thierry Keller, Gert Kwakkel, Tobias Nef, Nick Ward, Andreas R. Luft and Janne Marieke Veerbeek aims to develop an internationally harmonized core set of motor outcome measurements for clinical application, which should serve as a quality standard in clinical motor Rehabilitation after a Stroke .

Reward during arm training improves impairment and activity after a Stroke

A randomized controlled trial by Mario Widmer, Jeremia PO Held, Frieder Wittmann, Belen Valladares, Olivier Lambercy, Christian Sturzenegger, Antonella Palla, Kai Lutz, and Andreas R. Luft: Learning and learning-related Neuroplasticity in the motor cortex are possible mechanisms that mediate the restoration of motor function after a Stroke . These mechanisms depend on dopaminergic projections from the midbrain, which can encode reward information. The experience of therapists also confirms the importance of feedback and rewards for the effectiveness of post- Stroke training.
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